Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching
نویسندگان
چکیده
منابع مشابه
MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.
Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lacking the protein kinase MAP3K4 maintain properties of both stemness and epithelial-mesenchymal transition (EMT). Here, we show that MAP3K4 controls the activity of the histone a...
متن کاملCoordinated Output Regulation of Heterogeneous Linear Systems under Switching Topologies
This paper constructs a framework to describe and study the coordinated output regulation problem for multiple heterogeneous linear systems. Each agent is modeled as a general linear multiple-input multiple-output system with an autonomous exosystem which represents the individual offset from the group reference for the agent. The multi-agent system as a whole has a group exogenous state which ...
متن کاملDido3-dependent HDAC6 targeting controls cilium size
Primary cilia are involved in a variety of physiological processes such as sensing of the environment, cell growth and development. Numerous developmental disorders and pathologies arise from defects in these organelles. Multiple proteins that promote formation and disassembly of the primary cilium have been identified, but little is known about the mechanisms that control steady-state cilium s...
متن کاملEpigenetic regulation of interleukin-8 expression by class I HDAC and CBP in ovarian cancer cells
Although inhibitors of epigenetic regulators have been effective in the treatment of cutaneous T cell lymphoma (CTCL) and other hematopoietic malignancies, they have been less effective in solid tumors, including ovarian cancer (OC). We have previously shown that inhibition of histone deacetylase (HDAC) activity induces expression of the pro-inflammatory and pro-angiogenic chemokine interleukin...
متن کاملRegulation of Immune Responses by NF-κB/Rel Transcription Factors
W ithin peripheral lymphoid organs, complex interactions occur between lymphocytes and antigen-presenting cells during an immune response to antigen. Although there is considerable recognition of the fact that activation of innate immune signaling pathways is necessary for productive adaptive immune responses to occur, a great deal is still unknown about how this coordination is achieved at a m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Communications Biology
سال: 2020
ISSN: 2399-3642
DOI: 10.1038/s42003-020-01200-z